- Supplement Facts
- Reviews (6)
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Garcinia Cambogia is a fruit that is rich in the substance HCA (hydroxycitric acid), a naturally occurring molecule that has gained popularity for weight management. Numerous preliminary studies allegedly show HCA to possess weight loss properties via its ability to reduce appetite and oxidize fats, as well as lower the creation of new fats within the body 1, 2.
The mechanism by which HCA exerts its effect is believed to be via the inhibition of the enzyme “adenosine triphosphate-citrate lyase”, an enzyme that helps facilitate the conversion from citrate to acetyl-coenzyme A. This coenzyme is believed to play a key role in the synthesis of triglycerides and fatty acids, and thus its inhibition suggests a lower synthesis of new fats within the body 3. In addition to this, preliminary studies suggest HCA plays a role in regulating both serotonin and glucose levels, with the net effect being an overall reduction in appetite and feeling full from less food (increased satiety) 4.
A study investigating the role of Garcinia Cambogia 50% HCA extract supplementation in obese women (BMI > 25 kg/m(2) ) was conducted over a 60 day period. A reduction in the number of total bodily triglycerides was allegedly found 5.
A large scale meta-analysis examining 12 clinical trials involving Garcinia Cambogia HCA extracts found the supplement to have a statistically significant effect in weight reduction when compared to placebo, albeit the statistical significance was reportedly small. The review study noted that Garcinia Cambogia may have potential for short term weight management, however criticized the way a number of the clinical trials were conducted, and called for further research 6.
It may be the case that some individuals respond better than others to the fruit’s alleged benefits. In regards to dosage, it’s allegedly been shown according to at least one preliminary study that 500mg supplementation per day of Garcinia Cambogia HCA extract may lower bodily fat synthesis, at least in the short term 7. Caution is advised if you are taking anti-depressants that effect serotonin uptake, particularly selective serotonin reuptake inhibitors (SSRI’s), as these medications may combine with the effects of HCA and present potential serotonin syndrome toxicity 8. Other than this, Garcinia Cambogia seems to be generally well tolerated.
The above statements refer to the supplement/drug used within the cited research. Individual results and effectiveness of this supplement may vary. Always consult your physician before beginning supplementation.
1. Preuss, H.G., Rao, C.V.S., Garis, R., et al. J Med 35, 1-6 (2004), 33–48.
2. Shara, M., Ohia, S.E., Schmidt, R.E., et al. Mol. Cell. Biochem. 260, 1-2 (2004), 171–186.
3. Semwal, R.B., Semwal, D.K., Vermaak, I., and Viljoen, A. Fitoterapia 102, (2015), 134–148.
4. Chuah, L. O., Ho, W. Y., Beh, B. K. & Yeap, S. K. Evid Based Complement Alternat Med 2013, (2013).
5. Vasques, C.A.R., Schneider, R., et al. Phytother. Res. 28, 6 (2014), 887–891.
6. Onakpoya, I., Hung, S. K., Perry, R., Wider, B. & Ernst, E. J Obes 2011, (2011).
7. Kovacs, E.M.R. and Westerterp-Plantenga, M.S. J. Physiol. Behav 88, 4-5 (2006), 371–381.
8. Lopez, A.M., Kornegay, J., and Hendrickson, R.G. J. Med. Toxicol. 10, 4 (2014), 399–401.